A new Annihilation event threatens the cosmos! The war to end all wars is here, and the consequences will be grave for the Guardians of the Galaxy, S.W.O.R.D. and the royal couple of the united Kree/Skrull Empire, Hulkling and Wiccan! Five different planets have simultaneously come under threat, and this foe may be too big for even the new Guardians to handle. So it's a good thing that Cable is back - locked, loaded and ready to steal the ultimate weapon from the deadliest planet in X-history! Meanwhile, the Black Panther enlists the aid of the Intergalactic Empire of Wakanda and the legendary M'Baku! But what game is Doctor Doom playing? Not everyone is going to come home. Collecting GUARDIANS OF THE GALAXY (2020) #16-18, CABLE: RELOADED #1, THE LAST ANNIHILATION: WICCAN & HULKING, THE LAST ANNIHILATION: WAKANDA and S.W.O.R.D. (2020) #7.